IKAROS SETS THE THRESHOLD FOR NEGATIVE B-CELL SELECTION BY REGULATION OF THE SIGNALING STRENGTH OF THE AKT PATHWAY

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

Abstract Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection.Here, we show that SHIP1

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Penyelenggaraan Bimbingan dan Konseling di Sekolah Dasar

Abstract: This study is descriptive qualitative that aims to know the empirical evidence about the implementation of guidance and counseling at Public Elementary School Sungai Miai 5 Banjarmasin.The results showed that the implementation of guidance and counseling refers to the results of understanding of students.The strategy implemented consists

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Do cognitive impairments limit treatment gains in a standalone digital intervention for psychosis? A test of the digital divide

Digital mental health interventions, such as those provided by smartphone applications (apps), show promise as cost-effective approaches to increasing access to evidence-based psychosocial interventions for psychosis.Although it is well known that limited financial resources can reduce the benefits of digital approaches to mental healthcare, the ex

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Collecting Coins and Medals in 18th-Century Sweden

During the 18th century, collections of coins and medals were familiar sights.The collectors ranged from scholars to amateurs, men and women and the collectables tempted collectors for various reasons: they signified wealth and knowledge, they rendered historical events or current politics in material form, or they were miniature artworks and finan

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